Atonco

Alpha-immunotherapy against cancer

About Atonco

Astatine against cancer

Atonco is a clinical-stage radiopharmaceutical company developing innovative radiopharmaceutical products using astatine-211, an alpha particle-emitting radionuclide for the treatment of cancer. Founded in 2019 and built with an experienced and passionate team, Atonco was established on an exclusive license agreement with Telix Pharmaceuticals for the use of an antibody and a proprietary innovative astatine-211 radiolabeling technology targeting non-muscle-invasive bladder tumors (NMIBT).

Atonco, based on a disruptive and innovative alpha-immunotherapy, addresses two objectives:

Clinical indications with genuine unmet therapeutic needs

Rapidly accessible tumor targets, adapted to the short half-life of astatine-211 (7.2h) and whose small size is suited to the very short path length of the emitted alpha particles

Atonco Pharma - Alpha-immunotherapy
Source: Cyclotron Arronax (Wikipedia)
Mission

Offering cancer patients a longer life of better quality

The Atonco team aims to offer patients an innovative therapy to destroy the last remaining cancer cells of residual disease left after conventional cancer treatments, including radiotherapy, chemotherapy, and immunotherapy.

Future vision

“We believe that alpha-immunotherapy using astatine-211 holds great promise in certain clinical indications. Our vision is to confirm the future of alpha-immunotherapy as a promising targeted radiotherapy for better quality and longer lives for cancer patients.”

Team

A team of passionate experts

The Atonco team includes researchers, healthcare professionals, and medical industry experts who are highly experienced in their respective fields and very confident in the future of alpha-immunotherapy.

Jean-François Chatal

Jean-François Chatal, MD, PhD

Founder, CMO (Chief Medical Officer)

Jean-François Chatal, a pioneer in nuclear medicine, is an emeritus professor at the University of Nantes and the author of 204 publications. He served as head of the nuclear medicine departments at the Nantes University Hospital (CHU) and the cancer institute (ICC). He founded an INSERM laboratory at the University of Nantes (CRCINA) dedicated to the diagnostic and therapeutic use of radiolabeled monoclonal antibodies in oncology. In collaboration with Jacques Barbet from Immunotech, they were the first to demonstrate the relevance of pretargeting based on antibody use with a survival benefit of a radioimmunotherapeutic solution in a solid tumor. Their results targeting thyroid cancer were published in 2006 in the Journal of Clinical Oncology. Together with colleagues at the University of Nantes and with support from the Pays de la Loire region and the French government, Jean-François initiated the installation of a high-energy/high-intensity cyclotron, Arronax, in 2010 for the production of innovative radionuclides. He is also a co-founder of Atlab-Pharma in 2008 (sold to Telix in 2018), a company dedicated to the industrial development of radiolabeled antibodies for radioimmunotherapy, and of Naogen Pharma founded in 2016, a company developing a Rubidium-82 generator for cardiac imaging by Positron Emission Tomography (PET). In 2013, he was honored in Paris with the “Antoine Beclere Medal” awarded for his work in the development of nuclear medicine.

Sylvain Fanier

Sylvain Fanier, MSc, EMBA

President

Sylvain Fanier has dedicated his career to overseeing and leading the development of several global medical innovations in the healthcare sector, including neurosurgery, oncology, pain management, cardiovascular, electrophysiology, atrial fibrillation, 3D navigation systems, ultrasound, signal processing, radiation protection, shock waves, and molecular imaging and alpha-immunotherapy. He brings to the company leadership in strategy and a global perspective on business and financing, acquired over the past 30 years in large groups such as Johnson & Johnson and CR Bard, as well as in medical start-ups. Specializing in disruptive medical innovation, he has supported the success of innovative companies such as Lemerpax, Cardioinsight, Sonoscanner, Soundbite Medical Solutions, Surgivisio, and Med-Innov through his consulting firm, Novariver. He holds a degree in Biochemistry and a Master’s in Physiology from Paul Sabatier University in Toulouse. He also holds an EMBA from ESSEC, Paris, France. Sylvain is a board member of Soundbite Medical Solutions Inc. (Montreal, Canada) and a member of the strategic committees of Ecential Robotics SAS (Grenoble, France), Naogen Pharma, and Atonco (Nantes, France).

Alexandra Paillard

Alexandra (Giteau) Paillard, PharmD, PhD

COO (Chief Operating Officer)

Alexandra holds a Doctor of Pharmacy degree with more than twenty years of experience in Pharmaceutical Development, Quality Assurance, and CMC Regulatory Affairs. She began her career researching protein vectorization at the MINT – INSERM1066 laboratory at the University of Angers. Alexandra then worked on bringing medicines to market within pharmaceutical laboratories, start-ups, and consulting firms. She managed several pharmaceutical development projects and drafted around ten marketing authorization applications (quality section) at LFB, Biogaran, and ProductLife Group. Alexandra Paillard also contributed to setting up the quality system at the start-up DelleD up to obtaining authorization to open the Exploiting Pharmaceutical Establishment, and was responsible for Quality Assurance at Zach System, a manufacturer of pharmaceutical active ingredients. Today, Alexandra applies her experience at Atonco to the development of innovative radiopharmaceutical products in compliance with radiopharmaceutical regulations. Alexandra holds a Doctor of Pharmacy degree from the University of Angers and a PhD in pharmaceutical technology from the University of Paris-Sud.

Jacques Barbet

Jacques Barbet, PhD

CSO (Chief Scientific Officer)

Jacques Barbet brings to Atonco over 40 years of research experience in various fields, particularly in targeting radionuclides to tumor cells for imaging and therapy. Trained as an engineer at the École Polytechnique in Paris, he obtained his doctorate at the University of Paris VI and was appointed Research Director by the CNRS. He settled in Marseille at the Centre d’Immunologie de Marseille-Luminy, then joined Immunotech SA as head of the pretargeting project. He subsequently joined Jean-François Chatal’s group in Nantes to help set up GIP Arronax for more than 4 years. He contributed greatly to the development of nuclear medicine research in Nantes by leading the European FP7 TARCC project, the regional research program NucSan, and the PIA ArronaxPlus excellence equipment. In the meantime, he was one of the founding shareholders of Chelatec, Atlab Pharma (now acquired by Telix), and OGD2 Pharma. Retired in 2015 as a research director (exceptional class), he acts as principal scientific advisor for GIP Arronax, Chelatec, OGD2 Pharma, and Atonco.

Adrien Reymond

Adrien Reymond, Pharm.D/B.NG

Business Development Director

Adrien has more than 15 years of experience in the radiopharmaceutical industry, first as a pharmacist at Advanced Accelerator Applications (AAA, Novartis), then as chief pharmacist, president, and general manager of PETNET Solutions France (Siemens). Subsequently, Adrien served as project director at Atlanpole Biotherapies, the Nantes competitiveness cluster. The mission of the Pôle Santé Nord-Ouest, on behalf of the regional institution, is to assist public decision-makers in defining strategies to support the development of the Nantes radiopharmaceutical sector. Adrien advises various radiopharmacy leaders (Ipsen, Arronax). He has been involved in the development of innovative projects for several radiopharmaceutical companies since 2018 and has developed extensive experience in industrial operations, quality, and regulatory affairs with a broad network in the field of nuclear medicine. Adrien holds a Doctor of Pharmacy degree from the University Claude Bernard of Lyon, France, and a bachelor’s degree in chemical process engineering from Polytechnique Montréal, Canada.

Denis Bilodeau

Denis Bilodeau, BSc, DIA, MBA

Clinical Research Director

Denis brings diverse experience in patient care: clinical research on medical devices, pharmaceutical drug development, central laboratories, genomics, medical imaging, and cell therapy, within organizations such as Sandoz, Aventis, Genome Quebec, and the Montreal Heart Institute, at both national and international levels. He led one of Canada’s largest population genomics registries and has successfully conducted clinical research programs leading to US, Canadian, and European approvals. He is a member of the Ordre des administrateurs agréés du Québec. As Clinical Research Director, Denis will work closely with academic clinical research teams to implement Atonco’s clinical studies, including notably the one targeting bladder cancer. Denis holds an MBA from Concordia University, Montreal, and a BSc from Université Laval, Quebec.

Clément Mayeur

Clément Mayeur

CFO (Chief Financial Officer)

Clément Mayeur has more than 15 years of experience in corporate finance. He began his career in the audiovisual sector during the creation of the Orange Sport channel, then at TF1 in the mergers and acquisitions of production companies. In parallel, his career was enriched by entrepreneurial experiences that exposed him to the dynamics of company creation and development. After several years as a financial manager and then CFO in an international environment, he became a shared financial director and specialized in the MedTech and Biotech sectors. He brings to the company his expertise in corporate finance and in the implementation of a rigorous financial organization. He holds a master’s degree from Paris Dauphine University and the University of Reading in business finance, a postgraduate degree in intellectual property from Paris Sorbonne University, and a specialization in corporate finance from EDHEC Business School.

Advisors

Jean-Pierre Cabocel

Jean-Pierre Cabocel

EMBA, PhD Eng

Jean-Pierre brings to Atonco more than 30 years of experience in the field of nuclear medicine, notably as general manager of the radiopharmaceutical company Cis Bio International (now Curium Pharmaceuticals), a world leader in radiopharmaceuticals for medical imaging. He served as president of the AIPES association (Association of Imaging Producers and Equipment Suppliers), which brings together companies specializing in nuclear medicine, now known as Nuclear Medicine Europe (NME). Jean-Pierre Cabocel holds a doctorate in nuclear physics from the University of Lyon and an MBA from the Institut d’Administration et de Gestion des Entreprises (IAE) in Lyon.

Mario Campone

Mario Campone

MD, PhD

Mario Campone has been the general manager of the Institut de Cancérologie de l’Ouest (ICO) since June 2016. He obtained his doctorate at the University of Nantes. In addition, he holds a degree in cell biology and a university doctorate in life and health sciences. Part of his training was carried out at the Beatson Institute in Glasgow (UK). He is a professor of medical oncology at the University of Angers. He heads the phase I unit labeled by the Institut National du Cancer, and leads breast cancer research and translational research at the ICO in interaction with the transcriptomics (Cancer Genomics Joint Unit), proteomics, and bioinformatics platforms. He created the ORPHEO joint group with the National Veterinary School of Nantes. These activities aim to identify prognostic factors for breast cancer as well as predictive factors of response to targeted therapies. Mario Campone has been involved since 2003 in 26 studies as coordinator and principal investigator in 81 clinical studies in breast pathology. He is the author or co-author of more than 300 publications in peer-reviewed journals. He was president of the early study group (2012–2016) and vice-president of the personalized medicine group at UNICANCER (2015–2019). Since November 2015, he has been scientific director of the “Canceropole Grand Ouest.” Since 2019, he has been president of Unicancer (the French hospital network dedicated to fighting cancer).

Jean-Marc Le Doussal

Jean-Marc Le Doussal

PhD, EMBA

Jean-Marc Le Doussal is the founder and CEO of Remora Biotech, located in Lausanne, in the canton of Vaud, Switzerland. He created and developed Remora Capital SA with partner entrepreneurs to leverage their immunology expertise and, with supporting shareholders, they further develop advanced bio-therapeutic products that could change patients’ lives. In 2008, he founded and chaired ATLAB Pharma SAS, located in Nantes, Pays de la Loire, France. ATLAB Pharma SAS developed an antibody-targeted radiotherapy for the treatment of prostate cancer. It was acquired by Telix Pharmaceuticals located in Melbourne, Australia, in 2018. In 2011, he founded and chaired Activen SA located in Lausanne, Vaud, Switzerland. Activen develops miniproteins for the dermo-cosmetic industry. In 2014, he founded and chaired OGD2 Pharma located in Nantes, Pays de la Loire, France. OGD2 Pharma develops anticancer immunotherapies targeting O-acetylated GD2, a unique antigen with exquisite specificity for cancer compared to normal cells. The targeted clinical indications are deadly pediatric cancers, such as neuroblastoma, and adult cancers such as glioblastoma and triple-negative breast cancer. He is a graduate of the École Polytechnique in Paris, where he obtained a master’s degree and an engineering diploma. He obtained an Executive MBA in Management, Entrepreneurship, and Innovation from the École Polytechnique Fédérale de Lausanne, Switzerland.

Richard Valeix

Richard Valeix

MBA

Richard Valeix is an experienced leader in the biopharmaceutical sector, currently General Manager of the Telix Therapeutics group within Telix Pharmaceuticals Limited. Based in Geneva, he brings more than 20 years of international experience in oncology, endocrinology, and radiopharmaceuticals, combining scientific expertise with strategic vision in commercial and operational development. Holding a Doctor of Pharmacy degree from the University of Pharmacy in Marseille and a Master’s from ESCP Business School, Richard began his career at Roche Pharmaceuticals in oncology before joining Ipsen, where he held several positions of responsibility in global marketing and business unit management in the therapeutic areas of endocrinology and oncology. He continued his career at Advanced Accelerator Applications (AAA), where he held management positions for more than seven years, including Global Sales and Marketing Director and General Manager for France, Switzerland, and Benelux, actively contributing to the development of nuclear medicine and radioligand therapy solutions.

Atonco Team
Partnerships

Our strategic partners

Atonco collaborates with leading partners in the field of pharmaceutical research and medical innovation to accelerate the development of our therapies.

Telix Pharmaceuticals

An international company specializing in radiopharmaceuticals, Telix develops targeted diagnostic and therapeutic solutions for oncology and other serious conditions, combining medical innovation with precision medicine.

GIP Arronax

A research platform located in Saint-Herblain (44), dedicated to nuclear medicine, ensuring the production of innovative radionuclides (At-211, Pb-203, Cu-64…) and radiopharmaceuticals for early clinical phases (Phases 1 and 2).

CRCI2NA

The Centre de Search en Cancérologie et Immunologie Nantes-Angers (CRCI2NA) brings together researchers and clinicians to accelerate the discovery of new cancer treatments, from fundamental biology to translational medicine.

ICO

A reference institution in oncology, the ICO offers cutting-edge expertise across its territory. With its four missions — care, research, prevention, and education — the ICO provides patients with personalized care and access to therapeutic innovations.

Minerva Imaging

Based in Denmark, Minerva Imaging offers preclinical and translational research services, with recognized expertise in molecular imaging, radiopharmacy, and new drug development.

Ionetix

An American company specializing in radioisotope production, Ionetix designs comprehensive solutions for the manufacturing and distribution of radiopharmaceutical products for research and nuclear medicine.

Rigshospitalet

A major university hospital in Copenhagen, Rigshospitalet is recognized for its cutting-edge clinical research and its leading role in international clinical trials in oncology and radiotherapy.

University of Michigan

A major academic institution in the United States, the University of Michigan is distinguished by its advanced work in biomedical sciences and its collaborations with industry partners for the development of therapeutic biotechnologies.

Internal Pharmacy Satellite Unit (APUI) of Nantes University Hospital

The Nantes University Hospital has an internal pharmacy satellite unit within the ARRONAX cyclotron. This unit is responsible for the centralized production of radiopharmaceutical medicines for mono- and multi-center clinical trials.

Atlanpole

A Nantes technopole dedicated to innovation, Atlanpole supports the growth of regional biotech and deeptech companies by fostering synergies between research, industry, and funding.

Atlanpole Biothérapies

A national competitiveness cluster, Atlanpole Biothérapies brings together players in biotherapy and radiopharmacy around collaborative projects aimed at accelerating the transition from scientific research to clinical application.

CARE en Pays de la Loire

CARE en Pays de la Loire brings together regional healthcare players to promote innovation and excellence in the Loire region. This network unites public and private stakeholders committed to developing solutions and initiatives for patients, healthcare professionals, and the territory.